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During the experiments, it was observed that bla BKC-1 was easily lost in the absence of selective pressure. Abstract BKC-1 is a new class A serine carbapenemase that was recently identified in Klebsiella pneumoniae clinical isolates.

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Among the Klebsiella strains, These carbapenem resistance genes are frequently harbored on 50466 genetic elements that are highly transmissible, contributing to the increasing frequency of carbapenem-resistant Enterobacteriaceae 1. The other authors have no conflicts to declare.

In conclusion, prudent use of antimicrobials and strict adherence to infection control measures seem to be the only effective tools for preventing the acquisition and spread of new carbapenemase-encoding genes. J Clin Microbiol Nicolettia Silvia R. Performance standards for antimicrobial susceptibility testing; 25th informational 50446.

The principal objective of this study was to evaluate the frequency of bla BKC-1 by testing a collection of Klebsiella isolates. However, Southern blot analysis revealed that the bla BKC-1 gene was located on the same jjcm plasmid in both isolates.

Author information Article notes Copyright and License information Disclaimer. Published online Jul The Kpn and KpnJ strains showed resistance to all beta-lactams and fluoroquinolones. BKC-1 Brazilian Klebsiella carbapenemase is a class A serine carbapenemase that was recently identified in Klebsiella pneumoniae isolates from Brazil that belonged to sequence type ST clonal complex [CC] 2. Support Center Support Center. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard— 10th ed CLSI document MA Since BKC-1 is a weak carbapenemase and other mechanisms could be associated with carbapenemase production, we selected Klebsiella strains independent of the resistance phenotype.


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A total of Klebsiella strains collected from previous surveillance studies were randomly selected for this study, in order to represent distinct Brazilian geographic regions.

Plasmid extraction of K. Comparison of phenotypic tests for detecting BKCproducing Enterobacteriaceae isolates. Please review our privacy policy.

Frequency of BKCproducing Klebsiella species isolates. Kpn showed susceptibility to tigecycline 506, 0. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. In the past decade, carbapenemase-encoding genes such as bla KPC-likebla OXAand bla NDM-like have emerged as the main mechanisms of carbapenem resistance in Enterobacteriaceae.

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae. Martinsa Adriana G.

Open in a separate window. The two BKCproducing isolates belonged to clonal complex and possessed identical pulsed-field gel electrophoresis patterns. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates.

We verified that, in the absence of selective pressure, the plasmid harboring the bla BKC-1 gene, p, was unstable. S, sensitive; R, resistant. A Map of Brazil, showing the geographic distribution of Klebsiella isolates that were investigated for the bla BKC-1 gene.

J Antimicrob Chemother The bla BKC-1 gene was inserted into a kb plasmid that was identical to the previously reported plasmid, p More studies with greater numbers of isolates from all Brazilian states are necessary to assess the real prevalence of isolates carrying bla BKC In addition, bla BKC-1 was harbored by a small unstable plasmid that could be easily lost in the absence of selective pressure.


In this study, a low frequency of isolates carrying bla BKC-1 was observed and was mainly attributed to the persistence of a K. To date, inactivation of mgrB has been the main mechanism of polymyxin resistance observed in K. Antimicrob Agents Chemother The carbapenemase was encoded by bla BKC-1which was located on a small nonconjugative plasmid 2.

This article has been cited by other articles in PMC. Sampaiob, c and Ana C. Address correspondence to Willames M. Only 2 BKCproducing K.

Clinical and Laboratory Standards Institute. Initially, we performed transformation by electroporation into Escherichia coli Top The Kpn and KpnJ strains showed different plasmid profiles. Santosb Jorge L. Antimicrobial susceptibility testing was performed by the broth microdilution method, according to CLSI guidelines 45. These data jm suggest that, although genetically related, the isolates were probably subjected 504 distinct selective pressures, which could have resulted in different OMP modifications.

BKC-1 is a new class A serine carbapenemase that was recently identified in Klebsiella pneumoniae clinical isolates. National Center for Biotechnology InformationU. Diagn Microbiol Infect Dis jcj To evaluate the stability of p harbored by the Kpn isolate, we performed serial passages of the Kpn isolate on Mueller-Hinton agar plates without the addition of antibiotic.