Etude épidémiologique de la bronchite chronique dans une population agée de 60 à 85 ans. Contributions à l’étude de l’histoire naturelle de la. Les signes propres de la bronchite chronique distale et de l’emphysème au cours des syndromes de bronchopneumopathie dyspnéisante. Download Citation on ResearchGate | Physiopathologie de la toux | Cough is initiated from organs innervated by the vagus nerve. The larynx and the lower.

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Access to the full text of this article requires a subscription. It is suggested that mitochondrial metabolism is impaired in right ventricular bornchite. Vasoconstriction, vascular remodeling and pulmonary endothelial dysfunction contribute to the disease development and progression.

The RV was evaluated with parameters derived from pressure-volume loops, echocardiography, right heart catheterism and with circulating biomarkers. This work also showed the important role of FGF-2 protein and the recruitment of endothelial progenitor cells in neovascularization observed in thrombus of CTEPH patients. BPCO avec insuffisance respiratoire: French 15 Portuguese 1. Therefore, we analyzed the role of endothelial dysfunction in the control of two types of altered immune responses: BPCO Les broncho-pneumopathies chroniques obstructives.

This project allowed to study three biological process clearly establish to be implicated in chroniquw of PAH. Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. In our piglet model, we showed that impairment physiopxthologie right ventricular contractile reserve is strongly associated with ventricular-arterial uncoupling.

The nature of small-airway obstruction in chronic obstructive pulmonary disease. Thus, we showed that, in our swine CTEPH model, the mitochondrial respiratory capacities were globally and early impaired.

Facteurs pronostiques des BPCO.

Exacerbation de bronchite chronique: This study highlights the need for more specific RV indices phyaiopathologie PH. Journal page Archives Contents list. In this thesis we have shown implication of the progenitor cells and chemotactic axis in the vascular remodeling in human and experimental PAH.


Cellular and molecular determinants of right ventricular-pulmonary arterial coupling are misunderstood, while a wide functional range is remarkable among patients sharing the same degree of pulmonary physiopathologke resistance. The first aim of this thesis was to study the association between microvascularisation impairment and right ventricular physiopathokogie to chronic pressure overload. Is early recognition and treatment important?

The first model was a systemic-to-pulmonary shunt SHUNT between the aortic arch and the pulmonary trunk. You can move this window by clicking on the headline. We reproduced and described the main morphological and functional features observed in acute right heart failure on PH and we showed for the first time that acute right ventricular ischemic lesions may develop within few hours despite hemodynamic restauration with dobutamine. Agusti A, Vestbo J. Molecules targeting cellular proliferation induced by tyrosine kinases receptors TKR activation or oxidative stress OS seem to be potential therapeutic innovations.

Smoking characteristics – Differences in attitudes and bronchiye between healthy smokers and smokers with COPD.

BPCO – Bronchite Chronique – – Documentation sur les BPCO

These data provide a strong rational to develop specific biomarkers to evaluate tissue lesions of the right ventricle and determine their clinical implications. La bronchite chronique au quotidien. The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease – GOLD executive summary.

Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique (Ile-de-France)

As pulmonary vascular cells exhibit a cancer-like hyperproliferative and apoptotic-resistant phenotype in PAH, we hypothesized that the activation of pulmonary vascular NMDARs may contribute to the vascular remodeling leading to PAH.

The recent progress in the understanding of mechanisms at the origin of this disease underlines the role of extrapulmonary cells, such as circulating stem cells and bone marrow-derived progenitor cells in vascular remodeling and in PAH development.


Molecular pathways involved in both mechanisms are currently studied to find new targeted therapeutics. The balance between the supply and the increased need in oxygen is crucial to maintain an adapted right ventricular function. Taking together, these results showed that microvascular impairment and mitochondrial dysfunction btonchite an important role in the early right ventricular dysfunction.

The evaluation of these changes may be applied for screening, prognosis evaluation and follow-up of patients with PH. Underlying mechanisms of right ventricular dysfunction and failure in chronic pressure overload are complex and still subject to debate.

Use of spirometry for case finding, diagnosis and management of chronic obstructive pulmonary disease COPD. We divided the population by the median of the pulmonary vascular resistance PVR and we observed that in the group with worse hemodynamic severity this difference increased: Similarly, tyrosine kinase inhibitors have shown efficacy in PAH management but associated with severe adverse events as cardiac toxicity.

We also oberved experimentally in rats that structural and functional remodeling of the pressure overloaded right ventricle is associated withmacrophagic infiltration in the myocardium. We compared two different piglet models of pulmonary hypertension.

Patterns of dynamic hyperinflation during exercise and recovery in patients with severe chronic obstructive pulmonary disease. At early stage of PH the right ventricle RV remodels to adapt to the increased pulmonary vascular resistances. A wide review of anatomic, embryologic and physiologic concepts was performed to help for the understanding of parameters of RV evaluation; then published and ongoing original studies were presented.

In a third study, we highlighted that a strong relationship between ventricular-arterial coupling and functional and molecular plasticity of the pressure overloaded right ventricle.